The driver of a big rig that overturned on the westbound Foothill (210) Freeway in Pasadena suffered fatal injuries in the crash.
The fatality was reported about 6:30 p.m. just east of Lake Avenue, according to the California Highway Patrol.
An initial unconfirmed report from the scene indicated the big rig was involved in a collision with a pickup truck, according to the CHP.
The crash prompted closure of the Lake Avenue off-ramp, the CHP reported.
For more accident/crime news, a motorcyclist was killed in a crash in Angeles National Forest.